Quebec platelet disorder

Quebec platelet disorder

Quebec platelet disorder (QPD), also called Quebec platelet syndrome (QPS), is a congenital platelet disorder in which excessive production of uPA within platelet alpha granules is responsible for increased bleeding risk. The condition is extremely rare, with an estimated prevalence of 1:220,000 in Quebec, Canada and 1:655,000 ...PLAU, the gene that encodes uPA. The duplicated copy of the PLAU gene is placed in a region of DNA controlled by a strong megakaryocyte-specific transcriptional enhancer, markedly increasing its expression.